Upcoming Adrenal Technology- Twistject Cortisol Delivery Device Update

Adrenal Alternatives Foundation is a proud affiliate of SOLUtion medical, which is a company creating an auto-injecting device to deliver the life saving cortisol injection.

We were privileged to interview SOLUtion’s founder, Julia Anthony on the latest updates for the TWISTject device!

You can also listen to the full podcast episode:

  1. Please introduce yourself. 

Julia Anthony, Chief Executive Officer of SOLUtion Medical. 

  1. What form of adrenal disease were you diagnosed with?

I was diagnosed with Salt-Wasting Congenital Adrenal Hyperplasia (SWCAH) at birth. This is a rare, chronic, autosomal recessive genetic condition requiring daily medication for the rest of my life, and rescue injection during an adrenal crisis. 

  1. Can you tell us about SOLUtion medical?

SOLUtion Medical is developing a one-step injector for delivering adrenal crisis medication in a rescue situation. With our device we plan to eliminate the need for cumbersome and confusing rescue kits, and replace those kits with a single, one-step device.

  1. What updates can you tell us about upcoming developments for the TwistJect device?

Our device automatically mixes medication without requiring shaking or visual monitoring. Initial data shows our product mixes hydrocortisone sodium succinate powder approximately 20X faster than the current standard of care in only one user step. We are presently working to optimize our product for manufacturing. 

Our immediate goals are to complete the design process to define how our device will be manufactured in medically compliant manufacturing, a non-trivial process. We expect to obtain approvals throughout the world so our device can be obtained by anyone at risk of an adrenal crisis regardless of location.   

Longer term, we envision our device as applicable to many different drugs and treatments, allowing more at-home usage of a variety of medications requiring mixing directly prior to injection. 

  1. How will your invention change the future of adrenal crisis management?

By simplifying rescue injections, more sufferers of adrenal insufficiency will be empowered to carry and use their rescue medication. This will reduce mental burden, increase compliance, and improve the lives of those with adrenal insufficiency.

  1. What goals do you hope to accomplish with your work?

Virtually everyone at risk for an adrenal crisis must carry a rescue kit, and these kits are not straightforward or easy to use. As a result, too few people inject themselves with rescue medication at the onset of an adrenal crisis, resulting in longer hospital stays, lower quality of life, and even death. A simple, easy to use device will reduce complexity and difficulties of injections, providing an “EpiPen” like experience that is intended to improve compliance of rescue injections during an adrenal crisis. 

  1. What is the timeline for the availability of the TwistJect device?

Developing and obtaining regulatory approvals for a drug device combinatorial product can be a long process.  We are targeting late 2024 for product launch, with hopes of delivering the device sooner. Much depends on the time spent during the regulatory approval process. 

  1. How complex of a project is the creation of your device from concept to production?

It is fairly complex, especially because our product is a combinatorial product, meaning it combines two regulated components, the rescue drug and the drug delivery device. Manufacturing, testing, documentation, and other regulatory compliance add multiple layers of complexity on top of normal manufacturing adding to both time and cost. These processes are all individually understood, but combining them into a product such as this is certainly non-trivial.

  1. What is something you want to tell the adrenal community?

You and your voice matter. Use it – for yourself and to empower others in the adrenal and rare disease communities. 

  1. How do you balance work and living with adrenal disease?

The forever present and typically invisible (when well-managed) chronic condition that is SWCAH makes work-life balance – an already challenging equilibrium – even more difficult. I am lucky to be surrounded by a talented and passionate team who are understanding of my condition and its affects. At the end of the day, it is thinking about the individuals and families we aim to help through our work that keeps me going. 

For more information on SOLUtion medical you can visit their website: https://solutionmedllc.com/

The Adrenal Alternatives Foundation is registered with the IRS as a 501(c)3 nonprofit organization.

EIN: 83-3629121.

This information was brought to you by the Adrenal Alternatives Foundation for educational use only and is not meant to provide medical care or legal advice.

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  1. Bev says:

    This device really is needed! I can’t wait! Thanks for sharing the info!

  2. larry henderson says:

    i hope we get it soon

  3. Charlette Koger says:

    This would be a great feeling to know I had a epi pen that I could use with steroids to save my life. Also, to use in case of a critical car accident when one would sure be needed. EMS is not allowed to carry steroids on board.

  4. Susan E Swiney says:

    Wonderful! Thank you for your efforts. Stay healthy…..diagnosed in ‘18.

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